Low Pass Sequencing (1–3x Coverage)
Low pass sequencing is a cost-effective genomic approach that provides genome-wide coverage at low depth (1–3x). By combining this data with powerful imputation algorithms, it can identify common genetic variants across the genome, making it ideal for population-scale studies, polygenic risk scoring, and pre-screening applications.
Conditions Detected by Low Pass Sequencing
Common genetic
variant profiling
Polygenic risk score
calculation
Carrier status
identification
Population-scale
genetic screening
Genome Sequencing Solutions
Why It’s a Smart Choice
Genome-Wide Insight
Covers the entire genome at a low depth for broad variant detection through low pass genome sequencing.
Budget-Friendly
Reduces sequencing costs while retaining valuable genomic data and accuracy.
Imputation Power
Boosts accuracy by combining low pass sequencing with imputation from large reference panels.
Research Ready
Perfect for population genomics, biobank projects, and scalable screening efforts.
How It Works
Big Data. Simple Steps.
Sample Collection
Collect blood or saliva samples at our lab or with a home kit.
Sequencing & Imputation
Low pass genome sequencing is performed, followed by data imputation for high-resolution results.
Analysis & Output
A comprehensive report is generated, including variant data, risk scores, and clinical insights.
Why Choose FSG for Low Pass Sequencing
High-Quality Standards
We use advanced platforms to ensure data accuracy even at low sequencing depths.
Expert Data Analysis
Our team delivers high-confidence imputed results backed by clinical validation.
Scalable Solutions
Ideal for both individual diagnostics and large-scale research projects.
Trusted Facility
FSG is the UAE’s first certified molecular genomics lab offering full in-house solutions for low pass sequencing.
Frequently Asked
Questions!
We’re here to help. Explore answers or reach out to our team directly.
What is low pass genome sequencing?
Low pass genome sequencing is a genomic method where the entire genome is sequenced at a low depth, typically between 1–3x coverage. Although each base is read fewer times compared to traditional high-coverage sequencing, advanced imputation techniques are used to accurately predict genetic variants. This approach offers a cost-effective solution for broad genetic profiling, population studies, and risk assessment applications.
What are the three types of sequencing?
The three main types of sequencing are whole genome sequencing (WGS), whole exome sequencing (WES), and targeted sequencing. WGS covers the entire genome, WES focuses on the protein-coding regions, and targeted sequencing analyzes specific genes or regions of interest. Techniques like low pass sequencing are increasingly used within whole genome strategies to balance cost with comprehensive genomic insight.
What is low coverage sequencing?
Low coverage sequencing refers to sequencing a genome at a lower depth, usually between 1x and 5x, rather than the standard 30x or higher used for deep sequencing. Low pass sequencing is a form of low coverage sequencing that relies on statistical imputation to fill in missing data points, enabling accurate identification of common genetic variants while significantly reducing costs, making it ideal for large-scale research and screening projects.
What is ultra low pass whole genome sequencing?
Ultra low pass whole genome sequencing involves sequencing the genome at an extremely low depth, often below 1x coverage. Despite minimal initial data, imputation algorithms enhance the results, allowing for broad genomic analysis. This is particularly valuable in large population studies, biobanking, and preliminary genetic screening, where cost-effectiveness and scalability are critical.
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